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Insulin resistance alone does not result in the development of type 2 diabetes, and reports have shown that there must be progressive dysfunction of pancreatic islets, which disrupt the secretion of glucagon from the cells and insulin from cells, leading to uncontrolled hyperglycaemia, for the disease to develop [220]

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After one year without the supplementation, all parameters returned to basal values, indicating the need for daily supplementation to maintain the effects

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