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The ornithine generated by Arg1 metabolism is utilized by fibroblasts as a substrate for proline synthesis, ultimately exacerbating collagen production (180)

A study on peripheral neuropathy found B12 injections reduced pain and improved nerve function

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Unfortunately, to date, no treatment based on pathogenic considerations has shown clear positive effects and thus early institution of optimal glycemic control remains the only available measure with proven efficacy in preventing or halting progression of diabetic neuropathy
