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You may be more likely to need supplementation if you: are age 50 or older are pregnant have certain chronic health conditions take certain long-term medications eat a strictly meat-free diet Its important to remember that supplements arent regulated by the Food and Drug Administration (FDA), so you should only buy from a trusted, reputable brand
If you want a deeper breakdown of the science, Cymbiotika also explains glutathione in What Is Glutathione Good For Skin

Jimenez RV, Kuznetsova V, Connelly AN, Hel Z, Szalai AJ

The body does not make its own B12