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These findings collectively demonstrate that exercise training facilitates collateral vessel formation through multiple mechanisms, including miRNA expression regulation and local inflammatory response modulation

6 Future perspectives Metabolomics is to become an important tool in research related to the investigation of drug-induced hepatotoxicity, allowing researchers to assess the deleterious effects of xenobiotics by identifying changes in metabolite levels that uncover the toxic mechanisms at play, the identification of biomarkers of interest suitable for clinical diagnosis and facilitating the development of predictive models

Kidney Blood Press Res 38:31-41

The CNSs high metabolic demand renders it particularly vulnerable to oxidative injury