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The PS for adjustment of toxicities was composed using body surface area, age, histology, relapse after surgical resection, ECOG-PS, comorbidities, chemotherapy line, reduced dosage requirement status, and duration of premedication as independent variables, and the C-statistic of the ROC curve analysis was 0.808

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice

They also provide a lifeline to the many patients who are B12 deficient but remain untreated due to a within range result on a serum B12 test

There are several ways to increase B12 levels, but not all methods work the same for everyone