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ophiasis is characterized by a symmetrical band of hair loss along the occipital hairline that extends sinuously to the bitemporal area (Figure 4D)

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Specifically, AX upregulated peroxisome proliferator-activated receptor- coactivator 1-alpha (PGC-1) and mitochondrial transcription factor A (TFAM), key regulators of mitochondrial DNA replication and transcription, as well as oxidative phosphorylation (OXPHOS) complex proteins, resulting in increased mitochondrial DNA content and ATP production

In addition, the effectiveness is uncertain whenever recombinant OspA were used in three different doses, although it showed positive singnificant outcome