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Numerous in vitro studies show that ITCs induce apoptosis via both intrinsic and extrinsic pathways (108)for instance, through caspase activation (109), mitochondrial dysfunction (110), and oxidative stress generation (111)
Many drugs can cross the luminal cell membrane but are then metabolized in the gut wall (typically by CYP3A4 e.g
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The intranasal delivery can be utilized to alleviate drug delivery challenges on the battlefield to provide prehospital TBI treatment
