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Collagen Organization and Cross-Linking Raw collagen production matters less than how that collagen organizes itself

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Both 400 mcg/day and 5 mg /day FA significantly increased plasma folate and decreased plasma Hcy 5mg/day - but not 400 mcg/day folic acid improves blood vessel cell function in coronary artery disease patients as measured by flow mediated dilatation [27]

People with pernicious anemia or other medical conditions affecting B12 levels
