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Dec 29 2019;9(1)doi:10.3390/cells9010086 Chen YT, Chiang HJ, Chen CH, et al

Moreover, they stimulate the production of various pro-inflammatory mediators, including cytokines such as TNF and interleukins (IL-1 , IL-6, IL-12, IL-17, IL-18, IL-23), chemokines like CCL12 and CXCL10, as well as other pro-inflammatory agents, including ROS and RNS, inducible iNOS, and cyclooxygenase-2 (COX-2) 143

Step 1: Double Cleanse First cleanse: Use an oil-based cleanser or micellar water to remove makeup, sunscreen, and oil-based impurities Second cleanse: Use Kojiecare Kojic Acid + Turmeric Soap Follow the same technique as morning (6090 seconds total contact time) This ensures thorough cleansing and consistent brightening Step 2: Hydrating Toner Same as morningpat in gently to prep skin for treatment

Rakhmawati A, Wahyuni ET, Yuwono T
