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Besides upregulation of anti-oxidative stress capacity, another mechanism by which FoxO activation or low insulin drive may reduce oxidative stress includes the activation of Peroxisome Proliferator-activated receptor Gamma Coactivator 1 (PPGC-1), a nutrient sensing system that shifts substrate utilization towards fat and away from carbohydrate and increases mitochondrial biogenesis [66]

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doi: 10.1016/j.redox.2015.07.008 33 ZeeshanHMLeeGHKimHRChaeHJ

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Pharmacological ascorbate as an adjuvant for enhancing radiationchemotherapy responses in gastric adenocarcinoma

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Kim HM, Oh S, Choi CH, et al

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