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114 Lactate-fueled histone lactylation facilitates the activation of repair genes in macrophages

In response to a stressor, the hypothalamic-pituitary-adrenal (HPA) axis is activated, which triggers the cascade of hormonal response, including secretion of corticotropin (CRH), adrenocorticotropin (ACTH) from the brain and glucocorticoids (GC) from the adrenals (1)

Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss

Studies have found that it interacts with other cell death pathways such as apoptosis, necrosis, and pyroptosis ( At present, drug development for ferroptosis is still in its infancy, and the development of targeted drugs is progressing slowly