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This is explained further in the section below on joint hypermobility syndrome (JHS), hEDS, and hypermobility spectrum disorder (HSD)

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Though the drug is a diuretic agent that can assist horses in excreting up to 20 to 30 pounds in urine on race day and may have some impact on total circulating blood volume, it likely has an effect on the ability of vessels within the lungs to relax and accommodate greater volume expansion as well