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The formation of free radicals in turn prevented the formation of heat-induced heat shock proteins, thereby blocking the self-protection mechanism of cancer cells against heat

For the biodistribution study in diabetic rats, where technetium-99 m-albumin ( 99m Tc-BSA) was used for radiolabeling the nanoparticles, the radioactivity of the 99m Tc-BSA nanoparticles in the stomach wall increased only 60 min after oral administration and then decreased steeply in the stomach contents, and finally subsided to 50% decrease in transepithelial electrical resistance across the monolayer of Caco-2 cells, indicating that tight junctions between cells were loosened as a result of calcium binding and tyrosine phosphatase-mediated inhibition of occluding, a transmembrane protein that is involved in the closing of tight junctions (Fig

391 While its precise mechanismincluding potential NOX subunit (e.g., p67phox, p47phox) involvementrequires further elucidation, ZIO-101s dual action of ROS induction and mitochondrial impairment effectively promotes cancer cell death

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