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B12 after absorption in the bloodstream then binds to transcobalamin (TC) for systemic transport

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Center of mass distance for SIRT3/4FVT/ EGCG complex To find the stability of the designed ligands in complex with SIRT3/4fvt during the ligandprotein complex study (MD), the center of mass distance was analyzed between the ligand EGCG and the GLN 228 residue, as shown in Fig