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Moreover, plasma mtDNA copy number correlates positively with inflammatory cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-4, and IL-2 in depressed patients [40]
In addition, busulfan can interact with the glutathione and sulfhydryl groups and disrupt the cellular redox equilibrium, resulting in increased oxidative stress in cancer cells (36, 37)

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