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Treatment of intestinal epithelial cells with monoclonal JAM-A antibodies inhibited the resealing of the TJs, as indicated by delays in transepithelial electrical resistance (TER) recovery and occludin assembly.33 Recent studies have shown that JAM-A knockout mice exhibit higher permeability to dextran and myeloperoxidase activity in the colon compared to wild type mice
Ignatenko, O
optional extension to 16 weeks, followed by 24 week off-cycle
