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Moreover, whether the exosomes continuously secreted by the engineered cells, as a delivery vector themselves, will transfer the genetic modification effects laterally to distant tissue cells and thereby cause toxicity, is also an urgent issue that needs to be deeply clarified as a safety concern [168]

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AKT targets downstream proteins, such as BCL 2 -related death promoter (BAD), which, once dephosphorylated, form pro-apoptotic pores in the mitochondrial membrane and foster pore formation with BAK/BAX (30)

Cholesterol metabolism and transporter enzymes exert important effects on the production and activity of immune cells