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In addition, butyrate can activate the signaling pathway mediated by G protein-coupled receptors (GPRs), further inhibiting the downstream MEK-ERK and NF-B pathways

Am J Transl Res 2018;10:501-510

Other toxins that may also contribute to iodine deficiencies and thyroid dysfunction include nicotine, benzopyrenes, and hydroxylysine metabolites

Davis, E
