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I act out each one and the kids ROLL laughing because I am NOT an actress and am not the type to break out in improv

in BT549 cells, stable ELAVL1 knockdown also led to the same result (sh ELAVL1 and sh ELAVL1 II, Supplementary Fig

This extraordinary potency arises from the combination of the D-phenylalanine substitution at position 7, which confers enzymatic resistance and enhanced receptor binding geometry, the Nle substitution at position 4 that prevents methionine oxidation, and the cyclic lactam constraint that pre-organizes the pharmacophore into the bioactive conformation