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3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors (Tangpong et al., 2011)

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Bordet R., Ihl R., Korczyn A.D., Lanza G., Jansa J., Hoerr R., Guekht A

Importantly, directly comparing the single KO phenotype across four conditions highlighted 19 nutrient-dependent phenotypes that are otherwise mild in any single condition, which we termed GxE interactions (Fig