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Traditional bottom-up and top-down synthesis methods are classified as chemical and physical approaches, respectively

While several subtype-specific therapeutic approaches have been identified for SCLC 36,37,38,39,40,41 , recent evidence suggests that SCLC subtype intratumoral heterogeneity may evolve as a consequence of subtype plasticity 5 highlighting the need to devise therapies targeting SCLC plasticity rather than isolated molecular subtypes

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Although the recommended statements may be replicated in wording, firms have the flexibility to use alternate phrasing that convey the key messages of the recommended statements