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Together, our data suggest that secondary sulfonylurea failure may reflect islet cell reprogramming and loss of -cell identity, rather than simple -cell exhaustion To view or add a comment, sign in Clinical Efficacy of Second-Generation Tetracyclines as First-Line Systemic Agents for Gingival Lichen Planus In a recent JDD report of 254 biopsyconfirmed patients whose erythematous or erosive gingival oral lichen planus failed topical therapy, a 2month course of doxycycline or minocycline (100 mg twice daily), given alongside topical agents, produced clinical improvement in about 61% of patients

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Sections were then washed three times before being incubated with secondary antibodies (1:400, species-specific Alexa Flour 488, 555 or 647, Thermo Fisher Scientific), diluted in PBS for 2 h at room temperature on a shaker at 40 rpm