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FIGURE 1 The recently established understanding of the direct antioxidant activity of OH Py 2 N 2 through radical and transition metal scavenging, along with preliminary results suggesting catalytic protection via the Nrf2 pathway prompted the present studies focused on the therapeutic potential and activation of defensive antioxidant mechanisms induced by OH Py 2 N 2 to protect against oxidative stress in the eye (Johnston et al., 2019)

Interestingly, short-term overdose of green tea extract has a more significant effect on drug biotransformation enzymes than long-term small doses

Salehi B, Berkay Ylmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N (2019) Insights on the use of -lipoic acid for therapeutic purposes

The core mechanisms of autophagy, ferroptosis and their crosstalk are summarized in Fig