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Discov Onc 16 , 1612 (2025)

Two key structural features distinguish it from other GHRPs: (1) incorporation of an -aminoisobutyric residue (Aib) at position 1 replacing the histidine of classical GHRPs, stabilising the -turn conformation required for receptor activation, (2) presence of a D-2-naphthyl-alanine (D-2-Nal) at position 3 replacing the D-isomer tryptophan, increasing GHS-R1a selectivity over related receptors

Peer review Peer review information Nature Communications thanks Wei Jiang, Xiaoguang Liu, and the other anonymous reviewer(s) for their contribution to the peer review of this work

Canagliflozin, a SGLT-2 inhibitor, relieves ER stress, modulates autophagy and induces apoptosis in irradiated HepG2 cells: Signal transduction between PI3K/AKT/GSK-3beta/mTOR and Wnt/beta-catenin pathways