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However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression
On the one hand, ERCs suppress TGF- signaling and downregulate the proinflammatory cytokines IL-1 and TNF- by upregulating IL-10 (Sziksz et al., 2015)
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Furthermore, spatial transcriptomics technology enables us not only to identify the types of immune cells present in the TME but also to visually present their functional spatial distribution
