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Naliboff BD, Stephens AJ, Afari N et al: Widespread psychosocial difficulties in men and women with urologic chronic pelvic pain syndromes: Case-control findings from the multidisciplinary approach to the study of chronic pelvic pain research network

Generally speaking, a few weeks of supplementing is sufficient for you to start seeing some results, but if you want to reap maximum benefits, taking them daily is the most ideal

The purpose is maintaining optimal levels while the body completes the deeper structural repair that takes longest

But thats a short-term pharmacology effect that resolves within hours, not a long-term tolerance problem