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Consistent with these observations, oxygen consumption rates in C2C12 myotubes with ER knockdown were reduced significantly in this model

Lyophilized peptide powders offer superior stability compared to liquid formulations because the freeze-drying process removes water the primary driver of peptide degradation

In mammals, ascorbate is synthesised in the liver but, presumably because it is not made by humans, details of pathway control have received very little attention since the 1960s

However, PHGDH and SHMTs are also important for immune cells metabolism and function, at least against fungi and viral infections [123, 124], respectively, and the specific delivery of inhibitors to tumor cells might be the best therapeutic alternative in this case, not affecting immune cells-mediated antitumor immunity