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The efflux of cytochrome c from the mitochondria into the cytoplasm triggers the activation of pro-caspase-9, which in turn activates pro-caspase-3, ultimately leading to apoptosis [85]
The blood samples were obtained from HMC blood donor center in Doha, Qatar

doi: 10.1038/s41467-022-28720-y

10.1038/ng.2586 Nat