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Moreover, another study of DOX-induced nephrotoxicity in SD rats proved that L-theanine could protect the kidney by reducing the levels of oxidized glutathione (GSSG), gamma-glutamyltransferase 1 (GGT1), NF-B p65, and the percentage of apoptosis indexes in the tissue and plasma, and increasing the levels of GSH and the activities of GPx, glutathione reductase (GR), and glutathione S-transferase (GST) (86)

Treatment includes limb amputation or correction by Ilizarov method as a limb-sparing technique

MTHFR stands for methyl-tetrahydrofolate reductase, an enzyme that is responsible for the process of methylation in every cell in your body

In our study, a marked accumulation of the colocalization of bound/free GTP with small GTPases Arl8b and Rab7 in both genotypes suggests a lack of endolysosomal mobilization in old age neurons