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It has been demonstrated that all these pathological mechanisms triggered simultaneously by HI associated with IR produce, both directly and indirectly, through the triggering of arterial hypertension, an increase in LV mass, also due to an increase in intramyocardial and epicardial fat, with concentric LV remodeling, increased myocardial fibrosis, and diastolic dysfunction
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These are the energy-producing centres of cells, where fat is converted into usable energy

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