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Moreover, the evaluation of pigmented lesions in the oral cavity is further complicated by multifactorial etiologies, including endogenous factors like nevi and exogenous causes such as amalgam tattoos, making accurate diagnosis and management of these lesions pivotal in clinical practice

Previous clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC)

This effect was later reduced by the administration of the NMDA receptor antagonist, 2-amino-5-phosphonovaleric acid (Xie et al., 2017)