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Additionally, mutations in nDNA genes such as succinate dehydrogenase (SDH), fumarate hydratase (FH), isocitrate dehydrogenase 2 (IDH2), and IDH3 in the mitochondrial tricarboxylic acid (TCA) cycle were also observed to result in increasing levels of succinate, fumarate, or 2-hydroxyglutarate [208210]
doi: 10.1097/00004647-200112000-00003
