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Stromal cells acquire carbon and nitrogen from noncanonical sources to synthesize glutamine

274 Donepezil is an acetylcholinesterase inhibitor that promotes the activation of AMPK and inhibits the activation of the NF-B pathway by facilitating the expression of low-density lipoprotein receptor-associated protein 1, thereby reducing inflammation and intestinal epithelial apoptosis in the colon

This impairment manifests as reduced mitochondrial biogenesis, dysregulated mitochondrial dynamics (imbalances in fusion and fission), and inefficient mitophagy, collectively accelerating EC dysfunction, senescence, and atherosclerotic progression [161,162,163,164]

Patients who have been taking opioids for briefer periods of time may tolerate a more rapid taper