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However, the available literature is mainly based on preclinical studies and clinical studies are still in scarce to obtain some clear picture of the clinical effectiveness of polyphenols in the therapeutics of chronic fatigue

Wu, WK, YL Lo, JY Chiu, CL Hsu, IH Lo, S Panyod, et al

found that general control of amino acid synthesis 5 like 1 (GCN5L1) in mitochondria of liver cancer cells can promote the acetylation and inactivation of GLS1 and GLS2 isomers, thus inhibiting mTORC1 activation and cell proliferation

It is also widely available as a dietary supplement in several forms and is frequently promoted for fat burning, performance, recovery, heart health, and cognitive support