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After tipping off the supernatant, diluted supernatants were incubated for 2 hr at RT
In practical terms, that means far less antioxidant reserve at exactly the time when cells face more oxidative stress
In non-small cell lung cancer (NSCLC) cells, lactate downregulated glycolytic enzymes hexokinase 1 (HK-1) and pyruvate kinase (PKM) while upregulating tricarboxylic acid cycle enzymes succinate dehydrogenase A (SDHA) and isocitrate dehydrogenase 3 (IDH3G) mRNA levels [71]
Blood 107 (9), 37383744
