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The compound is also unusual among research peptides in showing dose-response activity across a six-log range Krivic 2006 reported tendon-to-bone healing benefit at 10 g/kg, 10 ng/kg, and 10 pg/kg in the same Wistar-rat model which is one reason researchers should be cautious in extrapolating any single preclinical dose to a "best dose" without further work

(2010) used 10 mcg/kg and 10 ng/kg in rats, both effective

Semaglutide is FDA-approved with clinical evidence