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Furthermore, the choriocapillaris density and diameter diminish as a function of age, and this process is pronounced in patients with early age-related macular degeneration (AMD) [26,83]

In science jargon-y terms, the title of my project was Using nanobiopsy and RNA analysis to investigate somatic instability of the CAG repeat in Huntingtons disease induced neurons. One reason we were interested in this was because, although, in general, the longer the inherited CAG tract, the earlier the individual is likely to start experiencing symptoms, there is a wide range of onset ages for patients with a moderate repeat number and one possible reason for this variability is variability in somatic expansion causing different cells to develop longer tracts and form more toxic protein

Similarly, HIF activators have also been shown to protect the lungs during ARDS 127,128 , and an ongoing trial is examining HIF activators for ARDS prevention 129