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More specifically, in vitro studies have shown that RES reduces inflammation in UC by decreasing IL-1 levels and increasing IL-11 production, primarily through the modulation of the Nrf2 pathway in both TNF- challenged Caco-2 cells and patient tissue samples [408]

Journal of Agricultural and Food Chemistry, 48 (4), 11501154

Some people may experience mild digestive changes like bloating or gas when first starting a supplement

This induced proximity facilitates polyubiquitination of the target protein, promoting its proteasomal degradation
