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Neurodegenerative diseases Similar to muscle diseases, neurodegenerative conditions present altered mitochondrial homeostasis and NAD + metabolism, which have been thoroughly investigated as targets for NAD + modulation-based approaches 13,268,269
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Additionally, B12 is involved in the metabolism of homocysteine, an amino acid that, when elevated, can increase the risk of heart disease
Its effects on fat tissue are indirect, mediated through downstream increases in endogenous GH and IGF-1
