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Knockdown studies of GPX4 results in a reduction in the expression of genes encoding components of Complex I, IV, and V [53], while overexpression of mitochondrial GPX4 prevents release of the proapoptotic molecule cytochrome C from mitochondria, suggesting a key role as an anti-apoptotic agent in mitochondrial death pathways [26]

Because free radicals are often considered to be "Public Enemy Number One" when it comes to cellular health, longevity and quality of life, you want antioxidants to neutralize them and protect against their damaging effects as quickly as possible

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The study were conducted in accordance with the local legislation and institutional requirements