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& Becker, C
doi: 10.1016/j.cell.2020.07.018 209 LinHChengJMuWZhouJZhuL
Melatonin use is safe and did not show any teratogenic effects in both human and animal (9-10) as well as no toxicity (11) even at very high dose (5-20mg/day)
Mechanical or inflammatory injury to the hypothalamus alters neuroendocrine secretion and contributes to systemic insulin resistance induced by inflammation/hyperglycemia, further impairing metabolic regulation and glucose uptake [60]
