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Hsieh from The University of Texas Southwestern Medical Center for tissue slide preparation

Molecular oxygen is then reduced to superoxide radicals, generating a redox cycle between the leukoaminochrome o -semiquinone radical and aminochrome [10, 36]

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To better mimic the complexity of the human brain, we differentiated brain organoids from iPSC of PSEN1-9 (depicted as AD-cBOs) and corresponding isogenic lines (depicted as Iso-cBOs) and studied whether ferroptosis-related proteins were altered in AD organoids