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After 3 y of treatment with zoledronic acid the incidence of symptoms, including arthralgia were significantly lower in the 1 group in compare with the 2 group (P = 0.01)

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(278) studied 14 healthy controls and 141 CKD patients, demonstrating that while plasma levels of protein-bound uremic toxins increased with CKD progression, fecal concentrations of these toxins and their precursors remained stable