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We retained DE candidates only when they satisfied both a P-value threshold ( 1)

The most frequently reported adverse events in the ALCAR/ALA group versus the placebo group included diarrhea (30% ALCAR/ALA vs 15% placebo), foul-smelling urine (25% vs 5%), rash (20% vs 0%), constipation (15% vs 5%), and dyspepsia (15% vs 0%)

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Ann Hematol, 1999
