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These studies suggest that antioxidants should be tried

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It also supports research on oxidative stress protection and senescence delay

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In addition to these, the augmentation of the EPR effect can also be done by employing some classical methods like a pharmaceutical-based approach, which includes the administration of angiotensin-II, bradykinin, and TNF-, or a physical approach such as hyperthermia, radiotherapy has the potential to be exploited for the partial improvement in the EPR-mediated tumor targeting (Table 2) [67, 68, 110], but they are not enough to treat the cancer patients suffering from non-leaky tumors, and therefore they could not be benefitted from the EPR principle

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