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As a result, free glutamine and/or alanine deriving from enteral Ala-Gln administration can be released into the bloodstream, thus making the amino acids available to target tissues, including the liver [183], immune system [39], kidneys [184] and skeletal muscles [53] (Figure 4)

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GSH-triggered prodrugs Because intracellular GSH levels are typically elevated in tumor cells relative to normal tissues, this redox imbalance has been exploited as a tumor-associated trigger for prodrug activation and selective cytotoxicity 214

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