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In activated macrophage cultures, GHK-Cu administration reduces the production of pro-inflammatory cytokines including interleukin-1, tumor necrosis factor-, and interleukin-6 by 40-65% while simultaneously increasing the production of anti-inflammatory mediators such as interleukin-10 and transforming growth factor-

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Thesignsandsymptomsof thedeficiencymay include anemia , the buildup of too much acid in the body (metabolic acidosis), frequent infections, andsymptomscaused by problems in the brain including seizures , intellectual disability , and loss of coordination ( ataxia )