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Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis

of Tennessee, Knoxville, TN Kevin Andrew Wood Re-programming Human Leukemia Cells: Changes in Gene Expression During Leukemia Cell Differentiation

The association between the genes of the -glutamyl cycle and autistic disorder is not well studied, although recently a relatively large study using a pathway approach showed a three-SNP joint interaction effect for glutaredoxin, glutaredoxin 3 and cystathione lyase (OR = 3.78, 95% CI: 2.36, 6.04) as well as marginal associations for cystathione lyase, the gamma-glutamylcysteine synthetase, catalytic subunit and glutaredoxin 3 suggesting that variation in genes involved in counterbalancing oxidative stress may contribute to autism [94]

Human data: two healthy adults tolerated 20 mg IV without adverse events (Lee & Burgess, 2025) the only formal human safety data