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Betaine was shown to suppress NLRP3 inflammasome activation and IL-1 production in the liver of diabetic mice by inhibiting insulin-induced activation of the FoxO1 transcription factor, leading to the activation of thioredoxin and hence suppression of ROS production in hepatocytes (Xia et al., 2018
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Similarly, FASN inhibition reverses CD8 T-cell exhaustion, thereby restoring the efficacy of PD-1 blockade in patients with HCC [136, 154]
