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Description
ATF4 (the same stress-responsive transcription factor that induces serine synthesis) also upregulates ASNS expression during amino acid deprivation or hypoxia, as asparagine becomes critical for cell survival under these conditions [57]
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ROS can induce the release of iron from mitochondrial ISC proteins of the respiratory chain, which will lead to further ROS production, establishing a vicious self-maintaining cycle
M., Peters, W
